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人诱导型一氧化氮合酶 Elisa试剂盒
物品单位 价格 品牌
2600 Solarbio
  • 产地:北京
  • 货号:SEKH-0501
  • 发布日期: 2020-08-10
  • 更新日期: 2020-08-10
产品详细说明
产地 北京
保存条件 -20
品牌 Solarbio
货号 SEKH-0501
检测方法 双抗体夹心法
CAS编号
保质期
规格
适应物种 Human
检测限 62.5-4000 pg/mL
数量 999
用途范围 Human
标记物
纯度 %
样本 血清/血浆/细胞培养上清
应用 Elisa试剂盒
是否进口
Inducible nitric oxide synthase (iNOS) is a widely expressed, approximately 130 kDa enzyme that catalyzes the conversion of L-arginine to nitric oxide (NO) plus citrulline. NO is a bioactive mediator that plays an important role in hemodynamics by inducing vascular smooth muscle relaxation. iNOS is constitutively expressed in the kidney. In other tissues, it is inducibly expressed during inflammation, oxidative stress, and hyperglycemia. iNOS activity is elevated in a variety of disease states including atherosclerosis, heart failure, sepsis, solid tumors, and type 2 diabetes. Increased production of NO mediates acute kidney injury, TNF-alpha induced muscle wasting, and the increased radiosensitivity of hypoxic tumor cells. Within amino acids 781-798, human iNOS shares 89% and 72% aa sequence identity with mouse and rat iNOS, respectively.
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