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人成纤维细胞生长因子10 Elisa试剂盒
物品单位 价格 品牌
2600 Solarbio
  • 产地:北京
  • 货号:SEKH-0425
  • 发布日期: 2020-08-10
  • 更新日期: 2020-08-10
产品详细说明
产地 北京
保存条件 -20
品牌 Solarbio
货号 SEKH-0425
检测方法 双抗体夹心法
CAS编号
保质期
规格
适应物种 Human
检测限 31.2 - 2000 pg/mL
数量 999
用途范围 Human
标记物
纯度 %
样本 血清/血浆/细胞培养上清
应用 Elisa试剂盒
是否进口
The Fibroblast Growth Factors (FGFs) are heparin binding glycoproteins that exert a variety of biological activities toward cells of mesenchymal, neuronal, and epithelial origin. FGF-10 belongs to the subgroup of FGFs that also includes FGF-3, -7, and -22. Mature human FGF-10 is an approximately 20 kDa protein that contains a serine-rich region near its N-terminus. It shares 93% and 96% amino acid sequence identity with mouse and rat FGF-10, respectively. FGF-10 is secreted by mesenchymal cells and associates with?extracellular FGF-BP. It preferentially binds and activates epithelial cell FGF?R2 (IIIb) and interacts more weakly with FGF?R1 (IIIb). The mitogenic and chemotactic properties of FGF-10 are critical in many tissues during embryogenesis. This includes limb bud initiation, palate development, branching morphogenesis and directional outgrowth of lung buds, formation of the otic vesicle and chochlea, adipogenesis, and the development of prostate, mammary, lacrimal, and submandibular salivary glands. FGF R2 (IIIb) signaling in these responsive tissues is similarly important during embryogenesis. The expression and function of FGF-10 are negatively regulated by Shh and BMP-4 in the developing lung. Overlapping expression patterns and activities with FGF-3, -7,?and -8 suggest at least a partial redundancy in FGF?10 biology. FGF-10 induced signaling through FGF R2 (IIIb) also contributes to the progression of pancreatic cancer.
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