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K009371PAnti-Phospho-Stat3-S727 Polyclonal Antibody
物品单位 价格 品牌
960 solarbio
  • 产地:北京
  • 货号:K009371P
  • 发布日期: 2020-03-04
  • 更新日期: 2020-03-05
产品详细说明
CAS编号
抗体名 Anti-Phospho-Stat3-S727 Polyclonal Antibody
是否单克隆
靶点 Phospho-Stat3-S727
用途范围 WB 1:500-2000. IHC 1:50-200. IP 1:50-100.
形态 液体
宿主 Rabbit
标记物
纯度 %
免疫原 A synthetic phosphorylated peptide around S727 of human Stat3
产地 北京
品牌 solarbio
货号 K009371P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
应用范围 WB IHC IP
抗原来源
保质期
规格 50ul
产品用途 蛋白研究,分析,检测
克隆性
适应物种 Human Mouse Rat
亚型 IgG
标识物
浓度 %
是否进口
背景资料:The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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